Title |
Epigenetic silencing of DSC3 is a common event in human breast cancer
|
---|---|
Published in |
Breast Cancer Research, June 2005
|
DOI | 10.1186/bcr1273 |
Pubmed ID | |
Authors |
Marc M Oshiro, Christina J Kim, Ryan J Wozniak, Damian J Junk, José L Muñoz-Rodríguez, Jeanne A Burr, Matthew Fitzgerald, Sangita C Pawar, Anne E Cress, Frederick E Domann, Bernard W Futscher |
Abstract |
Desmocollin 3 (DSC3) is a member of the cadherin superfamily of calcium-dependent cell adhesion molecules and a principle component of desmosomes. Desmosomal proteins such as DSC3 are integral to the maintenance of tissue architecture and the loss of these components leads to a lack of adhesion and a gain of cellular mobility. DSC3 expression is down-regulated in breast cancer cell lines and primary breast tumors; however, the loss of DSC3 is not due to gene deletion or gross rearrangement of the gene. In this study, we examined the prevalence of epigenetic silencing of DSC3 gene expression in primary breast tumor specimens. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 25% |
Chile | 1 | 25% |
United States | 1 | 25% |
Tunisia | 1 | 25% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 75% |
Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 4% |
Unknown | 47 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 7 | 14% |
Student > Bachelor | 6 | 12% |
Researcher | 6 | 12% |
Student > Master | 5 | 10% |
Professor | 4 | 8% |
Other | 7 | 14% |
Unknown | 14 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 20 | 41% |
Biochemistry, Genetics and Molecular Biology | 9 | 18% |
Medicine and Dentistry | 2 | 4% |
Immunology and Microbiology | 2 | 4% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
Other | 0 | 0% |
Unknown | 15 | 31% |