Title |
Expression profiling of serum inducible genes identifies a subset of SRF target genes that are MKL dependent
|
---|---|
Published in |
BMC Molecular and Cell Biology, August 2004
|
DOI | 10.1186/1471-2199-5-13 |
Pubmed ID | |
Authors |
Ahalya Selvaraj, Ron Prywes |
Abstract |
Serum Response Factor (SRF) is a transcription factor that is required for the expression of many genes including immediate early genes, cytoskeletal genes, and muscle-specific genes. SRF is activated in response to extra-cellular signals by its association with a diverse set of co-activators in different cell types. In the case of the ubiquitously expressed immediate early genes, the two sets of SRF binding proteins that regulate its activity are the TCF family of proteins that include Elk1, SAP1 and SAP2 and the myocardin-related MKL family of proteins that include MKL1 and MKL2 (also known as MAL, MRTF-A and -B and BSAC). In response to serum or growth factors these two classes of co-activators are activated by different upstream signal transduction pathways. However, it is not clear how they differentially activate SRF target genes. |
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