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Calpain-5 gene variants are associated with diastolic blood pressure and cholesterol levels

Overview of attention for article published in BMC Medical Genomics, January 2007
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Title
Calpain-5 gene variants are associated with diastolic blood pressure and cholesterol levels
Published in
BMC Medical Genomics, January 2007
DOI 10.1186/1471-2350-8-1
Pubmed ID
Authors

María E Sáez, María T Martínez-Larrad, Reposo Ramírez-Lorca, José L González-Sánchez, Carina Zabena, María J Martinez-Calatrava, Alejandro González, Francisco J Morón, Agustín Ruiz, Manuel Serrano-Ríos

Abstract

Genes implicated in common complex disorders such as obesity, type 2 diabetes mellitus (T2DM) or cardiovascular diseases are not disease specific, since clinically related disorders also share genetic components. Cysteine protease Calpain 10 (CAPN10) has been associated with T2DM, hypertension, hypercholesterolemia, increased body mass index (BMI) and polycystic ovary syndrome (PCOS), a reproductive disorder of women in which isunlin resistance seems to play a pathogenic role. The calpain 5 gene (CAPN5) encodes a protein homologue of CAPN10. CAPN5 has been previously associated with PCOS by our group. In this new study, we have analysed the association of four CAPN5 gene variants(rs948976A>G, rs4945140G>A, rs2233546C>T and rs2233549G>A) with several cardiovascular risk factors related to metabolic syndrome in general population.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 2%
New Zealand 1 2%
South Africa 1 2%
Unknown 38 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 22%
Researcher 7 17%
Student > Master 7 17%
Student > Bachelor 4 10%
Student > Doctoral Student 2 5%
Other 7 17%
Unknown 5 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 16 39%
Biochemistry, Genetics and Molecular Biology 4 10%
Medicine and Dentistry 4 10%
Nursing and Health Professions 2 5%
Chemistry 2 5%
Other 5 12%
Unknown 8 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 July 2018.
All research outputs
#8,533,995
of 25,371,288 outputs
Outputs from BMC Medical Genomics
#637
of 2,444 outputs
Outputs of similar age
#46,601
of 172,963 outputs
Outputs of similar age from BMC Medical Genomics
#1
of 5 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,444 research outputs from this source. They receive a mean Attention Score of 4.4. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 172,963 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them