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Asialoglycoprotein receptor (ASGPR): a peculiar target of liver-specific autoimmunity

Overview of attention for article published in Autoimmunity Highlights, October 2012
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (85th percentile)

Mentioned by

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4 patents
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4 Wikipedia pages

Citations

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65 Dimensions

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126 Mendeley
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Title
Asialoglycoprotein receptor (ASGPR): a peculiar target of liver-specific autoimmunity
Published in
Autoimmunity Highlights, October 2012
DOI 10.1007/s13317-012-0041-4
Pubmed ID
Authors

Dirk Roggenbuck, Maria G. Mytilinaiou, Sergey V. Lapin, Dirk Reinhold, Karsten Conrad

Abstract

Asialoglycoprotein receptor (ASGPR) autoantibodies have been considered specific markers of autoimmune hepatitis (AIH). The exact mechanisms responsible for the development of these autoantibodies and leading to autoimmunity to this peculiar liver receptor remain elusive. Furthermore, loss of T cell tolerance to ASGPR has been demonstrated in patients with AIH, but it is poorly understood whether such liver-specific T cell responses bear a pathogenic potential and/or participate in the precipitation of AIH. Newly developed enzyme-linked immunosorbent assays have led to the investigation of the sensitivity and specificity of anti-ASGPR antibodies for AIH. The present review provides an overview of the diagnostic and clinical relevance of anti-ASGPR antibodies. A thorough investigation of the autoreactivity against ASGPR may assist efforts to understand liver autoimmunity in susceptible individuals.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 126 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 126 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 24 19%
Student > Master 16 13%
Researcher 15 12%
Student > Bachelor 13 10%
Other 6 5%
Other 10 8%
Unknown 42 33%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 23 18%
Chemistry 21 17%
Agricultural and Biological Sciences 14 11%
Medicine and Dentistry 9 7%
Pharmacology, Toxicology and Pharmaceutical Science 8 6%
Other 9 7%
Unknown 42 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 November 2023.
All research outputs
#3,316,150
of 23,035,022 outputs
Outputs from Autoimmunity Highlights
#10
of 85 outputs
Outputs of similar age
#24,742
of 184,459 outputs
Outputs of similar age from Autoimmunity Highlights
#1
of 1 outputs
Altmetric has tracked 23,035,022 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 85 research outputs from this source. They receive a mean Attention Score of 4.3. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 184,459 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them