Title |
Examination of NRCAM, LRRN3, KIAA0716, and LAMB1as autism candidate genes
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Published in |
BMC Medical Genomics, May 2004
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DOI | 10.1186/1471-2350-5-12 |
Pubmed ID | |
Authors |
Holli B Hutcheson, Lana M Olson, Yuki Bradford, Susan E Folstein, Susan L Santangelo, James S Sutcliffe, Jonathan L Haines |
Abstract |
A substantial body of research supports a genetic involvement in autism. Furthermore, results from various genomic screens implicate a region on chromosome 7q31 as harboring an autism susceptibility variant. We previously narrowed this 34 cM region to a 3 cM critical region (located between D7S496 and D7S2418) using the Collaborative Linkage Study of Autism (CLSA) chromosome 7 linked families. This interval encompasses about 4.5 Mb of genomic DNA and encodes over fifty known and predicted genes. Four candidate genes (NRCAM, LRRN3, KIAA0716, and LAMB1) in this region were chosen for examination based on their proximity to the marker most consistently cosegregating with autism in these families (D7S1817), their tissue expression patterns, and likely biological relevance to autism. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 1 | 3% |
Australia | 1 | 3% |
Unknown | 32 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 8 | 24% |
Student > Ph. D. Student | 5 | 15% |
Student > Master | 5 | 15% |
Professor | 4 | 12% |
Student > Bachelor | 2 | 6% |
Other | 6 | 18% |
Unknown | 4 | 12% |
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Medicine and Dentistry | 9 | 26% |
Psychology | 4 | 12% |
Neuroscience | 4 | 12% |
Biochemistry, Genetics and Molecular Biology | 2 | 6% |
Other | 1 | 3% |
Unknown | 4 | 12% |