Title |
Upregulation of FOXM1 induces genomic instability in human epidermal keratinocytes
|
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Published in |
Molecular Cancer, February 2010
|
DOI | 10.1186/1476-4598-9-45 |
Pubmed ID | |
Authors |
Muy-Teck Teh, Emilios Gemenetzidis, Tracy Chaplin, Bryan D Young, Michael P Philpott |
Abstract |
The human cell cycle transcription factor FOXM1 is known to play a key role in regulating timely mitotic progression and accurate chromosomal segregation during cell division. Deregulation of FOXM1 has been linked to a majority of human cancers. We previously showed that FOXM1 was upregulated in basal cell carcinoma and recently reported that upregulation of FOXM1 precedes malignancy in a number of solid human cancer types including oral, oesophagus, lung, breast, kidney, bladder and uterus. This indicates that upregulation of FOXM1 may be an early molecular signal required for aberrant cell cycle and cancer initiation. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 56 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 17 | 30% |
Researcher | 8 | 14% |
Student > Master | 6 | 11% |
Student > Bachelor | 5 | 9% |
Professor > Associate Professor | 5 | 9% |
Other | 8 | 14% |
Unknown | 7 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 16 | 29% |
Biochemistry, Genetics and Molecular Biology | 15 | 27% |
Medicine and Dentistry | 10 | 18% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
Unspecified | 1 | 2% |
Other | 2 | 4% |
Unknown | 11 | 20% |