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The association of CD40 polymorphisms with CD40 serum levels and risk of systemic lupus erythematosus

Overview of attention for article published in BMC Genetics, October 2015
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  • Above-average Attention Score compared to outputs of the same age (62nd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (63rd percentile)

Mentioned by

patent
1 patent

Citations

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30 Dimensions

Readers on

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26 Mendeley
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Title
The association of CD40 polymorphisms with CD40 serum levels and risk of systemic lupus erythematosus
Published in
BMC Genetics, October 2015
DOI 10.1186/s12863-015-0279-8
Pubmed ID
Authors

Jian-Ming Chen, Jing Guo, Chuan-Dong Wei, Chun-Fang Wang, Hong-Cheng Luo, Ye-Sheng Wei, Yan Lan

Abstract

Current evidence shows that the CD40-CD40 ligand (CD40-CD40L) system plays a crucial role in the development, progression and outcome of systemic lupus erythematosus (SLE). The aim of this study was to investigate whether a CD40 gene single nucleotide polymorphism (SNP) is associated with SLE and CD40 expression in the Chinese population. We included controls (n = 220) and patients with either SLE (n =205) in the study. The gene polymorphism was measured using Snapshot SNP genotyping assays and confirmed by sequencing. We analyzed three single nucleotide polymorphisms of CD40 gene rs1883832C/T, rs1569723A/C and rs4810485G/T in 205 patients with SLE and 220 age-and sex-matched controls. Soluble CD40 (sCD40) levels were measured by ELISA. There were significant differences in the genotype and allele frequencies of CD40 gene rs1883832C/T polymorphism between the group of patients with SLE and the control group (P < 0.05). sCD40 levels were increased in patients with SLE compared with controls (P < 0.01). Moreover, genotypes carrying the CD40 rs1883832 C/T variant allele were associated with increased CD40 levels compared to the homozygous wild-type genotype in patients with SLE. The rs1883832C/T polymorphism of CD40 and its sCD40 levels were associated with SLE in the Chinese population. Our results suggest that CD40 gene may play a role in the development of SLE in the Chinese population.

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 4%
Unknown 25 96%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 4 15%
Researcher 4 15%
Student > Bachelor 3 12%
Student > Master 3 12%
Other 2 8%
Other 4 15%
Unknown 6 23%
Readers by discipline Count As %
Medicine and Dentistry 6 23%
Immunology and Microbiology 5 19%
Biochemistry, Genetics and Molecular Biology 4 15%
Agricultural and Biological Sciences 2 8%
Computer Science 1 4%
Other 2 8%
Unknown 6 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 September 2017.
All research outputs
#3,337,356
of 11,799,729 outputs
Outputs from BMC Genetics
#183
of 801 outputs
Outputs of similar age
#98,467
of 266,332 outputs
Outputs of similar age from BMC Genetics
#4
of 11 outputs
Altmetric has tracked 11,799,729 research outputs across all sources so far. This one is in the 49th percentile – i.e., 49% of other outputs scored the same or lower than it.
So far Altmetric has tracked 801 research outputs from this source. They receive a mean Attention Score of 3.3. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,332 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.