Title |
Praziquantel efficacy against Schistosoma mansoni among HIV-1 infected and uninfected adults living in fishing villages along Lake Victoria, Northwest Tanzania
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Published in |
Infectious Diseases of Poverty, December 2014
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DOI | 10.1186/2049-9957-3-47 |
Pubmed ID | |
Authors |
Humphrey D Mazigo, David W Dunne, Safari M Kinung’hi, Fred Nuwaha |
Abstract |
Animal studies have demonstrated that functional immune responses, as determined by the levels of CD4(+) cell counts and anti-schistosome antibodies responses, determine the efficacy of praziquantel. Based on this evidence, it has been hypothesised that the immunodeficiency effects of the human immunodeficiency virus (HIV)-1 infection may affect the efficacy of praziquantel in co-infected human hosts. Thus, the present study assessed the efficacy of praziquantel by comparing parasitological cure rates and the reduction in infection intensity in HIV-1 seronegative individuals infected with S. mansoni and HIV-1 seropositive individuals co-infected with S. mansoni, following treatment with a single oral dose of praziquantel. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Indonesia | 1 | 2% |
Tanzania, United Republic of | 1 | 2% |
Unknown | 41 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 10 | 23% |
Researcher | 8 | 19% |
Student > Bachelor | 5 | 12% |
Student > Ph. D. Student | 4 | 9% |
Student > Postgraduate | 3 | 7% |
Other | 7 | 16% |
Unknown | 6 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 23 | 53% |
Veterinary Science and Veterinary Medicine | 3 | 7% |
Agricultural and Biological Sciences | 3 | 7% |
Biochemistry, Genetics and Molecular Biology | 2 | 5% |
Social Sciences | 2 | 5% |
Other | 2 | 5% |
Unknown | 8 | 19% |