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Praziquantel efficacy against Schistosoma mansoni among HIV-1 infected and uninfected adults living in fishing villages along Lake Victoria, Northwest Tanzania

Overview of attention for article published in Infectious Diseases of Poverty, December 2014
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Title
Praziquantel efficacy against Schistosoma mansoni among HIV-1 infected and uninfected adults living in fishing villages along Lake Victoria, Northwest Tanzania
Published in
Infectious Diseases of Poverty, December 2014
DOI 10.1186/2049-9957-3-47
Pubmed ID
Authors

Humphrey D Mazigo, David W Dunne, Safari M Kinung’hi, Fred Nuwaha

Abstract

Animal studies have demonstrated that functional immune responses, as determined by the levels of CD4(+) cell counts and anti-schistosome antibodies responses, determine the efficacy of praziquantel. Based on this evidence, it has been hypothesised that the immunodeficiency effects of the human immunodeficiency virus (HIV)-1 infection may affect the efficacy of praziquantel in co-infected human hosts. Thus, the present study assessed the efficacy of praziquantel by comparing parasitological cure rates and the reduction in infection intensity in HIV-1 seronegative individuals infected with S. mansoni and HIV-1 seropositive individuals co-infected with S. mansoni, following treatment with a single oral dose of praziquantel.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Indonesia 1 2%
Tanzania, United Republic of 1 2%
Unknown 41 95%

Demographic breakdown

Readers by professional status Count As %
Student > Master 10 23%
Researcher 8 19%
Student > Bachelor 5 12%
Student > Ph. D. Student 4 9%
Student > Postgraduate 3 7%
Other 7 16%
Unknown 6 14%
Readers by discipline Count As %
Medicine and Dentistry 23 53%
Veterinary Science and Veterinary Medicine 3 7%
Agricultural and Biological Sciences 3 7%
Biochemistry, Genetics and Molecular Biology 2 5%
Social Sciences 2 5%
Other 2 5%
Unknown 8 19%