Title |
Prostanoid receptor EP1 and Cox-2 in injured human nerves and a rat model of nerve injury: a time-course study
|
---|---|
Published in |
BMC Neurology, January 2006
|
DOI | 10.1186/1471-2377-6-1 |
Pubmed ID | |
Authors |
Pascal F Durrenberger, Paul Facer, Maria A Casula, Yiangos Yiangou, Roy A Gray, Iain P Chessell, Nicola C Day, Sue D Collins, Sharon Bingham, Alex W Wilson, David Elliot, Rolfe Birch, Praveen Anand |
Abstract |
Recent studies show that inflammatory processes may contribute to neuropathic pain. Cyclooxygenase-2 (Cox-2) is an inducible enzyme responsible for production of prostanoids, which may sensitise sensory neurones via the EP1 receptor. We have recently reported that while macrophages infiltrate injured nerves within days of injury, they express increased Cox-2-immunoreactivity (Cox-2-IR) from 2 to 3 weeks after injury. We have now investigated the time course of EP1 and Cox-2 changes in injured human nerves and dorsal root ganglia (DRG), and the chronic constriction nerve injury (CCI) model in the rat. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 1 | 2% |
Unknown | 52 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 10 | 19% |
Researcher | 9 | 17% |
Student > Master | 6 | 11% |
Professor | 6 | 11% |
Student > Bachelor | 5 | 9% |
Other | 13 | 25% |
Unknown | 4 | 8% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 26 | 49% |
Agricultural and Biological Sciences | 10 | 19% |
Neuroscience | 4 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
Psychology | 2 | 4% |
Other | 5 | 9% |
Unknown | 4 | 8% |