Title |
Breast cancer in 30-year-old or younger patients: clinicopathologic characteristics and prognosis
|
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Published in |
World Journal of Surgical Oncology, February 2015
|
DOI | 10.1186/s12957-015-0462-4 |
Pubmed ID | |
Authors |
Yongqiang Yao, Mingqian Cao, Hong Fang, JiPing Xie |
Abstract |
The number of 30-year-old or younger patients with breast cancer is increasing. The aim was to describe the clinicopathological features and prognosis of 30-year-old or younger patients with breast cancer. We reviewed the records of 1,406 consecutive patients aged ≤50 years with first diagnosis of invasive breast cancer referred to surgery from March 2001 to March 2009. A total of 105 patients were aged ≤30 years (group I) and 1,301 were aged 31-50 years (group II). Compared with patients of group II, patients of group I had a higher percentage of tumors classified as estrogen receptors (ER) negative (P < 0.001) and progesterone receptors (PR) negative (P = 0.043), with a Ki-67 labeling index ≥20% of the cells (P = 0.011). There was no difference between the two groups for pT and pN, histology, endocrine therapy, and chemotherapy. The 5-year survival of group I was 67.5% as compared with 75.3% for group II (P = 0.003). Compared with patients aged between 31 and 50 years, patients aged ≤30 years have a greater chance of having an endocrine-unresponsive tumor and a significantly poor prognosis. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Uganda | 2 | 50% |
United States | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
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Science communicators (journalists, bloggers, editors) | 1 | 25% |
Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Scientists | 1 | 25% |
Members of the public | 1 | 25% |
Mendeley readers
Geographical breakdown
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Unknown | 24 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 5 | 21% |
Researcher | 3 | 13% |
Student > Bachelor | 2 | 8% |
Student > Doctoral Student | 2 | 8% |
Student > Postgraduate | 2 | 8% |
Other | 4 | 17% |
Unknown | 6 | 25% |
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Biochemistry, Genetics and Molecular Biology | 1 | 4% |
Psychology | 1 | 4% |
Nursing and Health Professions | 1 | 4% |
Social Sciences | 1 | 4% |
Other | 1 | 4% |
Unknown | 7 | 29% |