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The prototype HIV-1 maturation inhibitor, bevirimat, binds to the CA-SP1 cleavage site in immature Gag particles

Overview of attention for article published in Retrovirology, December 2011
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Mentioned by

wikipedia
1 Wikipedia page

Citations

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61 Dimensions

Readers on

mendeley
49 Mendeley
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Title
The prototype HIV-1 maturation inhibitor, bevirimat, binds to the CA-SP1 cleavage site in immature Gag particles
Published in
Retrovirology, December 2011
DOI 10.1186/1742-4690-8-101
Pubmed ID
Authors

Albert T Nguyen, Christa L Feasley, Ken W Jackson, Theodore J Nitz, Karl Salzwedel, Gillian M Air, Michael Sakalian

Abstract

Bevirimat, the prototype Human Immunodeficiency Virus type 1 (HIV-1) maturation inhibitor, is highly potent in cell culture and efficacious in HIV-1 infected patients. In contrast to inhibitors that target the active site of the viral protease, bevirimat specifically inhibits a single cleavage event, the final processing step for the Gag precursor where p25 (CA-SP1) is cleaved to p24 (CA) and SP1.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 1 2%
Unknown 48 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 14 29%
Researcher 7 14%
Student > Doctoral Student 6 12%
Student > Bachelor 5 10%
Student > Master 5 10%
Other 8 16%
Unknown 4 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 12 24%
Biochemistry, Genetics and Molecular Biology 10 20%
Chemistry 8 16%
Immunology and Microbiology 3 6%
Engineering 3 6%
Other 8 16%
Unknown 5 10%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 June 2012.
All research outputs
#8,534,528
of 25,373,627 outputs
Outputs from Retrovirology
#455
of 1,273 outputs
Outputs of similar age
#72,438
of 247,018 outputs
Outputs of similar age from Retrovirology
#8
of 14 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,273 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one has gotten more attention than average, scoring higher than 53% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 247,018 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.