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Arsenic trioxide induces apoptosis and the formation of reactive oxygen species in rat glioma cells

Overview of attention for article published in Cellular & Molecular Biology Letters, March 2018
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Title
Arsenic trioxide induces apoptosis and the formation of reactive oxygen species in rat glioma cells
Published in
Cellular & Molecular Biology Letters, March 2018
DOI 10.1186/s11658-018-0074-4
Pubmed ID
Authors

Yuanyuan Sun, Chen Wang, Ligang Wang, Zhibo Dai, Kongbin Yang

Abstract

Arsenic trioxide (As2O3) has a dramatic therapeutic effect on acute promyelocytic leukemia (APL) patients. It can also cause apoptosis in various tumor cells. This study investigated whether As2O3has an antitumor effect on glioma and explored the underlying mechanism. MTT and trypan blue assays showed that As2O3remarkably inhibited growth of C6 and 9 L glioma cells. Cell viability decreased in glioma cells to a greater extent than in normal glia cells. The annexin V-FITC/PI and Hoechest/PI staining assays revealed a significant increase in apoptosis that correlated with the duration of As2O3treatment and occurred in glioma cells to a greater extent than in normal glial cells. As2O3treatment induced reactive oxygen species (ROS) production in C6 and 9 L cells in a time-dependent manner. Cells pretreated with the antioxidant N-acetylcysteine (NAC) showed significantly lower As2O3-induced ROS generation. As2O3significantly inhibited the expression of the anti-apoptotic gene Bcl-2, and upregulated the proapoptotic gene Bax in both C6 and 9 L glioma cells in a time-dependent manner. As2O3can significantly inhibit the growth of glioma cells and it can induce cell apoptosis in a time- and concentration-dependent manner. ROS were found to be responsible for apoptosis in glioma cells induced by As2O3. These results suggest As2O3is a promising agent for the treatment of glioma.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 17 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 24%
Student > Bachelor 3 18%
Student > Master 3 18%
Researcher 3 18%
Professor 1 6%
Other 1 6%
Unknown 2 12%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 3 18%
Pharmacology, Toxicology and Pharmaceutical Science 2 12%
Medicine and Dentistry 2 12%
Agricultural and Biological Sciences 1 6%
Computer Science 1 6%
Other 3 18%
Unknown 5 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 April 2018.
All research outputs
#10,187,066
of 12,755,705 outputs
Outputs from Cellular & Molecular Biology Letters
#85
of 193 outputs
Outputs of similar age
#205,150
of 273,403 outputs
Outputs of similar age from Cellular & Molecular Biology Letters
#1
of 1 outputs
Altmetric has tracked 12,755,705 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 193 research outputs from this source. They receive a mean Attention Score of 2.3. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 273,403 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them