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Mendeley readers
| Title |
Proteasome-mediated degradation antagonizes critical levels of the apoptosis-inducing C1D protein
|
|---|---|
| Published in |
Cancer Cell International, September 2002
|
| DOI | 10.1186/1475-2867-2-12 |
| Pubmed ID | |
| Authors |
Karsten Rothbarth, Hermann Stammer, Dieter Werner |
| Abstract |
The C1D gene is expressed in a broad spectrum of mammalian cells and tissues but its product induces apoptotic cell death when exceeding a critical level. Critical levels are achieved in a fraction of cells by transient transfection with EGFP-tagged C1D expression constructs. However, transfected cells expressing sub-critical levels of C1D(EGFP) escape apoptotic cell death by activation of a proteasome-mediated rescue mechanism. Inhibition of the proteasome-dependent degradation of the C1D(EGFP) protein results in a parallel increase of the intracellular C1D level and in the fraction of apoptotic cells. |
Mendeley readers
The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 8 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 2 | 25% |
| Lecturer | 1 | 13% |
| Other | 1 | 13% |
| Student > Master | 1 | 13% |
| Professor | 1 | 13% |
| Other | 0 | 0% |
| Unknown | 2 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 3 | 38% |
| Agricultural and Biological Sciences | 3 | 38% |
| Unknown | 2 | 25% |