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Mendeley readers
| Title |
The interrelationship between DRIM gene expression and cytogenetic and phenotypic characteristics in human breast tumor cell lines
|
|---|---|
| Published in |
BMC Genomics, September 2003
|
| DOI | 10.1186/1471-2164-4-39 |
| Pubmed ID | |
| Authors |
Steve Goodison, Carrie Viars, Maren Grazzini, Virginia Urquidi |
| Abstract |
In order to facilitate the identification of genes involved in the metastatic phenotype we have previously developed a pair of cell lines from the human breast carcinoma cell line MDA-MB-435, which have diametrically opposite metastatic potential in athymic mice. Differential display analysis of this model previously identified a novel gene, DRIM (down regulated in metastasis), the decreased expression of which correlated with metastatic capability. DRIM encodes a protein comprising 2785 amino acids with significant homology to a protein in yeast and C. elegans, but little else is currently known about its function or pattern of expression. In a detailed analysis of the DRIM gene locus we quantitatively evaluated gene dosage and the expression of DRIM transcripts in a panel of breast cell lines of known metastatic phenotype. |
Mendeley readers
The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 8 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 3 | 38% |
| Librarian | 1 | 13% |
| Student > Doctoral Student | 1 | 13% |
| Other | 1 | 13% |
| Student > Ph. D. Student | 1 | 13% |
| Other | 1 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 3 | 38% |
| Medicine and Dentistry | 2 | 25% |
| Computer Science | 1 | 13% |
| Biochemistry, Genetics and Molecular Biology | 1 | 13% |
| Unknown | 1 | 13% |