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Mendeley readers
Attention Score in Context
| Title |
Identification of the hASCT2-binding domain of the Env ERVWE1/syncytin-1 fusogenic glycoprotein
|
|---|---|
| Published in |
Retrovirology, July 2006
|
| DOI | 10.1186/1742-4690-3-41 |
| Pubmed ID | |
| Authors |
Valérie Cheynet, Guy Oriol, François Mallet |
| Abstract |
The cellular HERV-W envelope/syncytin-1 protein, encoded by the envelope gene of the ERVWE1 proviral locus is a fusogenic glycoprotein probably involved in the formation of the placental syncytiotrophoblast layer. Syncytin-1-induced in vitro cell-cell fusion is dependent on the interaction with hASCT2. As no receptor binding domain has been clearly defined in the SU of neither the HERV-W Env nor the retroviruses of the same interference group, we designed an in vitro binding assay to evaluate the interaction of the HERV-W envelope with the hASCT2 receptor. Using truncated HERV-W SU subunits, a region consisting of the N-terminal 124 amino acids of the mature SU glycoprotein was determined as the minimal receptor-binding domain. This domain contains several sub-domains which are poorly conserved among retroviruses of this interference group but a region of 18 residus containing the SDGGGX2DX2R conserved motif was proved to be essential for syncytin-1-hASCT2 interaction. |
Mendeley readers
The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Iran, Islamic Republic of | 1 | 2% |
| Brazil | 1 | 2% |
| Unknown | 43 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 11 | 24% |
| Student > Ph. D. Student | 11 | 24% |
| Student > Bachelor | 6 | 13% |
| Student > Master | 4 | 9% |
| Other | 3 | 7% |
| Other | 6 | 13% |
| Unknown | 4 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 15 | 33% |
| Agricultural and Biological Sciences | 14 | 31% |
| Medicine and Dentistry | 4 | 9% |
| Immunology and Microbiology | 4 | 9% |
| Psychology | 2 | 4% |
| Other | 2 | 4% |
| Unknown | 4 | 9% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 November 2023.
All research outputs
#3,715,112
of 25,002,811 outputs
Outputs from Retrovirology
#162
of 1,145 outputs
Outputs of similar age
#8,503
of 79,264 outputs
Outputs of similar age from Retrovirology
#1
of 9 outputs
Altmetric has tracked 25,002,811 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,145 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 79,264 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them