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Mendeley readers
Attention Score in Context
| Title |
Asthma families show transmission disequilibrium of gene variants in the vitamin D metabolism and signalling pathway
|
|---|---|
| Published in |
Respiratory Research, April 2006
|
| DOI | 10.1186/1465-9921-7-60 |
| Pubmed ID | |
| Authors |
Matthias Wjst, Janine Altmüller, Theresia Faus-Kessler, Christine Braig, Margret Bahnweg, Elisabeth André |
| Abstract |
The vitamin D prophylaxis of rickets in pregnant women and newborns may play a role in early allergic sensitization. We now asked if an already diseased population may have inherited genetic variants in the vitamin D turnover or signalling pathway. Serum levels of calcidiol (25-OH-D3) and calcitriol (1,25-(OH)2-D3) were retrospectively assessed in 872 participants of the German Asthma Family Study. 96 DNA single base variants in 13 different genes were genotyped with MALDI-TOF and a bead array system. At least one positive SNP with a TDT of p < 0.05 for asthma or total IgE and calcidiol or calcitriol was seen in IL10, GC, IL12B, CYP2R1, IL4R, and CYP24A1. Consistent strong genotypic association could not be observed. Haplotype association were found only for CYP24A1, the main calcidiol degrading enzyme, where a frequent 5-point-haplotype was associated with asthma (p = 0.00063), total IgE (p = 0.0014), calcidiol (p = 0.0043) and calcitriol (p = 0.0046). Genetic analysis of biological pathways seem to be a promising approach where this may be a first entry point into effects of a polygenic inherited vitamin D sensitivity that may affect also other metabolic, immunological and cancerous diseases. |
Mendeley readers
The data shown below were compiled from readership statistics for 86 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| Unknown | 85 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 18 | 21% |
| Researcher | 14 | 16% |
| Student > Master | 14 | 16% |
| Student > Bachelor | 9 | 10% |
| Student > Doctoral Student | 7 | 8% |
| Other | 15 | 17% |
| Unknown | 9 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 34 | 40% |
| Agricultural and Biological Sciences | 16 | 19% |
| Biochemistry, Genetics and Molecular Biology | 8 | 9% |
| Nursing and Health Professions | 4 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 3% |
| Other | 10 | 12% |
| Unknown | 11 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 April 2010.
All research outputs
#6,597,909
of 25,374,917 outputs
Outputs from Respiratory Research
#813
of 3,062 outputs
Outputs of similar age
#24,425
of 84,362 outputs
Outputs of similar age from Respiratory Research
#6
of 16 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 3,062 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.9. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 84,362 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.