Title |
Building the synovium: cadherin-11 mediates fibroblast-like synoviocyte cell-to-cell adhesion
|
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Published in |
Arthritis Research & Therapy, January 2005
|
DOI | 10.1186/ar1495 |
Pubmed ID | |
Authors |
Hans P Kiener, Michael B Brenner |
Abstract |
Specific adhesion among like cells is a key determinant of the architecture of tissues. Homophilic (like binds like) adhesive interactions between cells are mediated by cadherins. These integral membrane glycoproteins have a crucial role in tissue morphogenesis during development and the maintenance of tissue integrity in adults. There is also an increasing recognition of a regulatory role for cadherins in a variety of cell functions, including cell migration. The recent identification of cadherin-11 expression in fibroblast-like synoviocytes (FLSs) has shed light on the mechanisms of synovial tissue organization and differentiation. Moreover, cadherin-11 expression in FLSs might also provide insight into pathways that determine the mesenchymal tissue response of the synovium to inflammation. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 2% |
Italy | 1 | 2% |
Austria | 1 | 2% |
Unknown | 44 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 10 | 21% |
Student > Doctoral Student | 6 | 13% |
Student > Bachelor | 6 | 13% |
Student > Postgraduate | 5 | 11% |
Researcher | 4 | 9% |
Other | 9 | 19% |
Unknown | 7 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 12 | 26% |
Medicine and Dentistry | 10 | 21% |
Biochemistry, Genetics and Molecular Biology | 7 | 15% |
Engineering | 5 | 11% |
Chemical Engineering | 1 | 2% |
Other | 5 | 11% |
Unknown | 7 | 15% |