Title |
RuleMonkey: software for stochastic simulation of rule-based models
|
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Published in |
BMC Bioinformatics, July 2010
|
DOI | 10.1186/1471-2105-11-404 |
Pubmed ID | |
Authors |
Joshua Colvin, Michael I Monine, Ryan N Gutenkunst, William S Hlavacek, Daniel D Von Hoff, Richard G Posner |
Abstract |
The system-level dynamics of many molecular interactions, particularly protein-protein interactions, can be conveniently represented using reaction rules, which can be specified using model-specification languages, such as the BioNetGen language (BNGL). A set of rules implicitly defines a (bio)chemical reaction network. The reaction network implied by a set of rules is often very large, and as a result, generation of the network implied by rules tends to be computationally expensive. Moreover, the cost of many commonly used methods for simulating network dynamics is a function of network size. Together these factors have limited application of the rule-based modeling approach. Recently, several methods for simulating rule-based models have been developed that avoid the expensive step of network generation. The cost of these "network-free" simulation methods is independent of the number of reactions implied by rules. Software implementing such methods is now needed for the simulation and analysis of rule-based models of biochemical systems. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 5% |
United Kingdom | 2 | 3% |
Germany | 1 | 2% |
Unknown | 54 | 90% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 16 | 27% |
Researcher | 14 | 23% |
Professor > Associate Professor | 6 | 10% |
Student > Bachelor | 5 | 8% |
Student > Master | 4 | 7% |
Other | 9 | 15% |
Unknown | 6 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 19 | 32% |
Computer Science | 14 | 23% |
Biochemistry, Genetics and Molecular Biology | 9 | 15% |
Mathematics | 2 | 3% |
Engineering | 2 | 3% |
Other | 8 | 13% |
Unknown | 6 | 10% |