Title |
Tim50a, a nuclear isoform of the mitochondrial Tim50, interacts with proteins involved in snRNP biogenesis
|
---|---|
Published in |
BMC Molecular and Cell Biology, July 2005
|
DOI | 10.1186/1471-2121-6-29 |
Pubmed ID | |
Authors |
Hongzhi Xu, Z Brad Somers, Melvin L Robinson, Michael D Hebert |
Abstract |
The Cajal body (CB) is a nuclear suborganelle involved in the biogenesis of small nuclear ribonucleoproteins (snRNPs), which are vital for pre-mRNA splicing. Newly imported Sm-class snRNPs traffic through CBs, where the snRNA component of the snRNP is modified, and then target to other nuclear domains such as speckles and perichromatin fibrils. It is not known how nascent snRNPs localize to the CB and are released from this structure after modification. The marker protein for CBs, coilin, may play a role in snRNP biogenesis given that it can interact with snRNPs and SMN, the protein mutated in Spinal Muscular Atrophy. Loss of coilin function in mice leads to significant viability and fertility problems and altered CB formation. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 2 | 8% |
Unknown | 22 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 6 | 25% |
Student > Ph. D. Student | 3 | 13% |
Student > Bachelor | 2 | 8% |
Student > Master | 2 | 8% |
Professor | 1 | 4% |
Other | 2 | 8% |
Unknown | 8 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 9 | 38% |
Biochemistry, Genetics and Molecular Biology | 3 | 13% |
Neuroscience | 2 | 8% |
Medicine and Dentistry | 2 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 4% |
Other | 0 | 0% |
Unknown | 7 | 29% |