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Morphine Induces Endocytosis of Neuronal μ-opioid Receptors Through the Sustained Transfer of Gα Subunits to RGSZ2 Proteins

Overview of attention for article published in Molecular Pain, July 2007
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1 Wikipedia page

Citations

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38 Dimensions

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31 Mendeley
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Title
Morphine Induces Endocytosis of Neuronal μ-opioid Receptors Through the Sustained Transfer of Gα Subunits to RGSZ2 Proteins
Published in
Molecular Pain, July 2007
DOI 10.1186/1744-8069-3-19
Pubmed ID
Authors

María Rodríguez-Muñoz, Elena de la Torre-Madrid, Pilar Sánchez-Blázquez, Javier Garzón

Abstract

In general, opioids that induce the recycling of mu-opioid receptors (MORs) promote little desensitization, although morphine is one exception to this rule. While morphine fails to provoke significant internalization of MORs in cultured cells, it does stimulate profound desensitization. In contrast, morphine does promote some internalization of MORs in neurons although this does not prevent this opioid from inducing strong antinociceptive tolerance.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Australia 1 3%
Canada 1 3%
Unknown 29 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 32%
Student > Ph. D. Student 5 16%
Student > Master 3 10%
Other 3 10%
Student > Doctoral Student 2 6%
Other 7 23%
Unknown 1 3%
Readers by discipline Count As %
Agricultural and Biological Sciences 12 39%
Neuroscience 5 16%
Pharmacology, Toxicology and Pharmaceutical Science 3 10%
Biochemistry, Genetics and Molecular Biology 3 10%
Medicine and Dentistry 3 10%
Other 2 6%
Unknown 3 10%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 May 2011.
All research outputs
#8,533,995
of 25,371,288 outputs
Outputs from Molecular Pain
#190
of 669 outputs
Outputs of similar age
#25,460
of 68,925 outputs
Outputs of similar age from Molecular Pain
#1
of 3 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 669 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one has gotten more attention than average, scoring higher than 61% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 68,925 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them