Title |
Association of GATA3, P53, Ki67 status and vascular peritumoral invasion are strongly prognostic in luminal breast cancer
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Published in |
Breast Cancer Research, April 2009
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DOI | 10.1186/bcr2249 |
Pubmed ID | |
Authors |
Jocelyne Jacquemier, Emmanuelle Charafe-Jauffret, Florence Monville, Benjamin Esterni, Jean Marc Extra, Gilles Houvenaeghel, Luc Xerri, François Bertucci, Daniel Birnbaum |
Abstract |
Breast cancers are traditionally divided into hormone-receptor positive and negative cases. This classification helps to guide patient management. However, a subgroup of hormone-receptor positive patients relapse irrespective of hormonal therapy. Gene expression profiling has classified breast tumours into five major subtypes with significant different outcome. The two luminal subtypes, A and B, show high expression of ESR1, GATA3 and FOXA1 genes. Prognostic biomarkers for oestrogen receptor (ER)-positive cases include progesterone receptor (PR) and androgen receptor (AR), and proteins related to proliferation or apoptotic resistance. The aim of this study was to identify the best predictors of success of hormonal therapy. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Iran, Islamic Republic of | 1 | 1% |
Japan | 1 | 1% |
Germany | 1 | 1% |
Unknown | 71 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 16 | 22% |
Student > Ph. D. Student | 9 | 12% |
Professor > Associate Professor | 9 | 12% |
Other | 8 | 11% |
Student > Master | 8 | 11% |
Other | 15 | 20% |
Unknown | 9 | 12% |
Readers by discipline | Count | As % |
---|---|---|
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Agricultural and Biological Sciences | 20 | 27% |
Biochemistry, Genetics and Molecular Biology | 6 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
Environmental Science | 1 | 1% |
Other | 4 | 5% |
Unknown | 12 | 16% |