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Glutathione S-Transferase Ω 1 variation does not influence age at onset of Huntington's disease

Overview of attention for article published in BMC Medical Genomics, March 2004
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Title
Glutathione S-Transferase Ω 1 variation does not influence age at onset of Huntington's disease
Published in
BMC Medical Genomics, March 2004
DOI 10.1186/1471-2350-5-7
Pubmed ID
Authors

Larissa Arning, Peter Jagiello, Stefan Wieczorek, Carsten Saft, Jürgen Andrich, Jörg T Epplen

Abstract

Huntington's disease (HD) is a fully penetrant, autosomal dominantly inherited disorder associated with abnormal expansions of a stretch of perfect CAG repeats in the 5' part of the IT15 gene. The number of repeat units is highly predictive for the age at onset (AO) of the disorder. But AO is only modestly correlated with repeat length when intermediate HD expansions are considered. Circumstantial evidence suggests that additional features of the HD course are based on genetic traits. Therefore, it may be possible to investigate the genetic background of HD, i.e. to map the loci underlying the development and progression of the disease. Recently an association of Glutathione S-Transferase Omega 1 (GSTO1) and possibly of GSTO2 with AO was demonstrated for, both, Alzheimer's (AD) and Parkinson's disease (PD).

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 8 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 38%
Student > Doctoral Student 1 13%
Other 1 13%
Student > Master 1 13%
Professor > Associate Professor 1 13%
Other 0 0%
Unknown 1 13%
Readers by discipline Count As %
Neuroscience 3 38%
Medicine and Dentistry 2 25%
Arts and Humanities 1 13%
Unknown 2 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 June 2017.
All research outputs
#8,534,976
of 25,374,647 outputs
Outputs from BMC Medical Genomics
#637
of 2,444 outputs
Outputs of similar age
#22,022
of 65,058 outputs
Outputs of similar age from BMC Medical Genomics
#2
of 4 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,444 research outputs from this source. They receive a mean Attention Score of 4.4. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 65,058 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.