Title |
Glutathione S-Transferase Ω 1 variation does not influence age at onset of Huntington's disease
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Published in |
BMC Medical Genomics, March 2004
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DOI | 10.1186/1471-2350-5-7 |
Pubmed ID | |
Authors |
Larissa Arning, Peter Jagiello, Stefan Wieczorek, Carsten Saft, Jürgen Andrich, Jörg T Epplen |
Abstract |
Huntington's disease (HD) is a fully penetrant, autosomal dominantly inherited disorder associated with abnormal expansions of a stretch of perfect CAG repeats in the 5' part of the IT15 gene. The number of repeat units is highly predictive for the age at onset (AO) of the disorder. But AO is only modestly correlated with repeat length when intermediate HD expansions are considered. Circumstantial evidence suggests that additional features of the HD course are based on genetic traits. Therefore, it may be possible to investigate the genetic background of HD, i.e. to map the loci underlying the development and progression of the disease. Recently an association of Glutathione S-Transferase Omega 1 (GSTO1) and possibly of GSTO2 with AO was demonstrated for, both, Alzheimer's (AD) and Parkinson's disease (PD). |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 3 | 38% |
Student > Doctoral Student | 1 | 13% |
Other | 1 | 13% |
Student > Master | 1 | 13% |
Professor > Associate Professor | 1 | 13% |
Other | 0 | 0% |
Unknown | 1 | 13% |
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Arts and Humanities | 1 | 13% |
Unknown | 2 | 25% |