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The dynamic cilium in human diseases

Overview of attention for article published in PathoGenetics, May 2009
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (79th percentile)

Mentioned by

patent
2 patents
wikipedia
3 Wikipedia pages

Citations

dimensions_citation
82 Dimensions

Readers on

mendeley
87 Mendeley
citeulike
1 CiteULike
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Title
The dynamic cilium in human diseases
Published in
PathoGenetics, May 2009
DOI 10.1186/1755-8417-2-3
Pubmed ID
Authors

Anna D'Angelo, Brunella Franco

Abstract

Cilia are specialized organelles protruding from the cell surface of almost all mammalian cells. They consist of a basal body, composed of two centrioles, and a protruding body, named the axoneme. Although the basic structure of all cilia is the same, numerous differences emerge in different cell types, suggesting diverse functions. In recent years many studies have elucidated the function of 9+0 primary cilia. The primary cilium acts as an antenna for the cell, and several important pathways such as Hedgehog, Wnt and planar cell polarity (PCP) are transduced through it. Many studies on animal models have revealed that during embryogenesis the primary cilium has an essential role in defining the correct patterning of the body. Cilia are composed of hundreds of proteins and the impairment or dysfunction of one protein alone can cause complete loss of cilia or the formation of abnormal cilia. Mutations in ciliary proteins cause ciliopathies which can affect many organs at different levels of severity and are characterized by a wide spectrum of phenotypes. Ciliary proteins can be mutated in more than one ciliopathy, suggesting an interaction between proteins. To date, little is known about the role of primary cilia in adult life and it is tempting to speculate about their role in the maintenance of adult organs. The state of the art in primary cilia studies reveals a very intricate role. Analysis of cilia-related pathways and of the different clinical phenotypes of ciliopathies helps to shed light on the function of these sophisticated organelles. The aim of this review is to evaluate the recent advances in cilia function and the molecular mechanisms at the basis of their activity.

Mendeley readers

The data shown below were compiled from readership statistics for 87 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 3 3%
Netherlands 1 1%
France 1 1%
Brazil 1 1%
Unknown 81 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 20 23%
Researcher 20 23%
Student > Master 13 15%
Student > Bachelor 7 8%
Professor > Associate Professor 6 7%
Other 13 15%
Unknown 8 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 49 56%
Biochemistry, Genetics and Molecular Biology 11 13%
Medicine and Dentistry 8 9%
Chemistry 2 2%
Business, Management and Accounting 1 1%
Other 5 6%
Unknown 11 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 December 2019.
All research outputs
#3,486,216
of 17,355,315 outputs
Outputs from PathoGenetics
#1
of 5 outputs
Outputs of similar age
#59,985
of 297,816 outputs
Outputs of similar age from PathoGenetics
#1
of 1 outputs
Altmetric has tracked 17,355,315 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.2. This one scored the same or higher as 4 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 297,816 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them