Title |
Semi-supervised protein subcellular localization
|
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Published in |
BMC Bioinformatics, January 2009
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DOI | 10.1186/1471-2105-10-s1-s47 |
Pubmed ID | |
Authors |
Qian Xu, Derek Hao Hu, Hong Xue, Weichuan Yu, Qiang Yang |
Abstract |
Protein subcellular localization is concerned with predicting the location of a protein within a cell using computational method. The location information can indicate key functionalities of proteins. Accurate predictions of subcellular localizations of protein can aid the prediction of protein function and genome annotation, as well as the identification of drug targets. Computational methods based on machine learning, such as support vector machine approaches, have already been widely used in the prediction of protein subcellular localization. However, a major drawback of these machine learning-based approaches is that a large amount of data should be labeled in order to let the prediction system learn a classifier of good generalization ability. However, in real world cases, it is laborious, expensive and time-consuming to experimentally determine the subcellular localization of a protein and prepare instances of labeled data. |
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Geographical breakdown
Country | Count | As % |
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Malaysia | 1 | 4% |
United Kingdom | 1 | 4% |
United States | 1 | 4% |
Greece | 1 | 4% |
Unknown | 19 | 83% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 8 | 35% |
Professor > Associate Professor | 4 | 17% |
Student > Bachelor | 4 | 17% |
Other | 2 | 9% |
Student > Doctoral Student | 1 | 4% |
Other | 1 | 4% |
Unknown | 3 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Computer Science | 12 | 52% |
Agricultural and Biological Sciences | 3 | 13% |
Engineering | 2 | 9% |
Biochemistry, Genetics and Molecular Biology | 1 | 4% |
Medicine and Dentistry | 1 | 4% |
Other | 1 | 4% |
Unknown | 3 | 13% |