Title |
A structure filter for the Eukaryotic Linear Motif Resource
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Published in |
BMC Bioinformatics, October 2009
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DOI | 10.1186/1471-2105-10-351 |
Pubmed ID | |
Authors |
Allegra Via, Cathryn M Gould, Christine Gemünd, Toby J Gibson, Manuela Helmer-Citterich |
Abstract |
Many proteins are highly modular, being assembled from globular domains and segments of natively disordered polypeptides. Linear motifs, short sequence modules functioning independently of protein tertiary structure, are most abundant in natively disordered polypeptides but are also found in accessible parts of globular domains, such as exposed loops. The prediction of novel occurrences of known linear motifs attempts the difficult task of distinguishing functional matches from stochastically occurring non-functional matches. Although functionality can only be confirmed experimentally, confidence in a putative motif is increased if a motif exhibits attributes associated with functional instances such as occurrence in the correct taxonomic range, cellular compartment, conservation in homologues and accessibility to interacting partners. Several tools now use these attributes to classify putative motifs based on confidence of functionality. |
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Geographical breakdown
Country | Count | As % |
---|---|---|
India | 1 | 3% |
Germany | 1 | 3% |
Australia | 1 | 3% |
Brazil | 1 | 3% |
Unknown | 29 | 88% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 10 | 30% |
Student > Ph. D. Student | 9 | 27% |
Student > Master | 4 | 12% |
Student > Bachelor | 4 | 12% |
Professor > Associate Professor | 3 | 9% |
Other | 2 | 6% |
Unknown | 1 | 3% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 21 | 64% |
Computer Science | 4 | 12% |
Biochemistry, Genetics and Molecular Biology | 3 | 9% |
Chemical Engineering | 1 | 3% |
Immunology and Microbiology | 1 | 3% |
Other | 2 | 6% |
Unknown | 1 | 3% |