Title |
Impact of ε and θ subunits on pharmacological properties of α3β1 GABAA receptors expressed in Xenopus oocytes
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Published in |
BMC Pharmacology, January 2006
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DOI | 10.1186/1471-2210-6-1 |
Pubmed ID | |
Authors |
Martin Ranna, Saku T Sinkkonen, Tommi Möykkynen, Mikko Uusi-Oukari, Esa R Korpi |
Abstract |
Gamma-aminobutyric acid type A (GABAA) receptors provide the main inhibitory control in the brain. Their heterogeneity may make it possible to precisely target drug effects to selected neuronal populations. In situ hybridization using rat brain sections has revealed a unique expression of GABAA receptor epsilon and theta subunit transcripts in the locus coeruleus, where they are accompanied at least by alpha3, alpha2, beta1 and beta3 subunits. Here, we studied the pharmacology of the human alpha3beta1, alpha3beta1epsilon, alpha3beta1theta and alpha3beta1epsilontheta receptor subtypes expressed in Xenopus oocytes and compared them with the gamma2 subunit-containing receptors. |
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