Title |
The influence of serotonin- and other genes on impulsive behavioral aggression and cognitive impulsivity in children with attention-deficit/hyperactivity disorder (ADHD): Findings from a family-based association test (FBAT) analysis
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Published in |
Behavioral and Brain Functions, October 2008
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DOI | 10.1186/1744-9081-4-48 |
Pubmed ID | |
Authors |
Robert D Oades, Jessica Lasky-Su, Hanna Christiansen, Stephen V Faraone, Edmund JS Sonuga-Barke, Tobias Banaschewski, Wai Chen, Richard JL Anney, Jan K Buitelaar, Richard P Ebstein, Barbara Franke, Michael Gill, Ana Miranda, Herbert Roeyers, Aribert Rothenberger, Joseph A Sergeant, Hans-Christoph Steinhausen, Eric A Taylor, Margaret Thompson, Philip Asherson |
Abstract |
Low serotonergic (5-HT) activity correlates with increased impulsive-aggressive behavior, while the opposite association may apply to cognitive impulsiveness. Both types of impulsivity are associated with attention-deficit/hyperactivity disorder (ADHD), and genes of functional significance for the 5-HT system are implicated in this disorder. Here we demonstrate the separation of aggressive and cognitive components of impulsivity from symptom ratings and test their association with 5-HT and functionally related genes using a family-based association test (FBAT-PC). |
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Unknown | 216 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 32 | 14% |
Student > Master | 30 | 13% |
Student > Bachelor | 22 | 10% |
Other | 18 | 8% |
Other | 51 | 22% |
Unknown | 30 | 13% |
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Neuroscience | 20 | 9% |
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Other | 23 | 10% |
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