Title |
Neuregulin3 alters cell fate in the epidermis and mammary gland
|
---|---|
Published in |
BMC Developmental Biology, September 2007
|
DOI | 10.1186/1471-213x-7-105 |
Pubmed ID | |
Authors |
Heena Panchal, Olivia Wansbury, Suzanne Parry, Alan Ashworth, Beatrice Howard |
Abstract |
The Neuregulin family of ligands and their receptors, the Erbb tyrosine kinases, have important roles in epidermal and mammary gland development as well as during carcinogenesis. Previously, we demonstrated that Neuregulin3 (Nrg3) is a specification signal for mammary placode formation in mice. Nrg3 is a growth factor, which binds and activates Erbb4, a receptor tyrosine kinase that regulates cell proliferation and differentiation. To understand the role of Neuregulin3 in epidermal morphogenesis, we have developed a transgenic mouse model that expresses Nrg3 throughout the basal layer (progenitor/stem cell compartment) of mouse epidermis and the outer root sheath of developing hair follicles. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 3% |
Brazil | 1 | 3% |
Unknown | 36 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 10 | 26% |
Researcher | 6 | 16% |
Professor | 3 | 8% |
Professor > Associate Professor | 3 | 8% |
Student > Bachelor | 2 | 5% |
Other | 7 | 18% |
Unknown | 7 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 21 | 55% |
Biochemistry, Genetics and Molecular Biology | 4 | 11% |
Medicine and Dentistry | 2 | 5% |
Computer Science | 1 | 3% |
Veterinary Science and Veterinary Medicine | 1 | 3% |
Other | 0 | 0% |
Unknown | 9 | 24% |