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Mendeley readers
Attention Score in Context
| Title |
Channel-mediated astrocytic glutamate modulates hippocampal synaptic plasticity by activating postsynaptic NMDA receptors
|
|---|---|
| Published in |
Molecular Brain, February 2015
|
| DOI | 10.1186/s13041-015-0097-y |
| Pubmed ID | |
| Authors |
Hyungju Park, Kyung-Seok Han, Jinsoo Seo, Jaekwang Lee, Shashank M Dravid, Junsung Woo, Heejung Chun, Sukhee Cho, Jin Young Bae, Heeyoung An, Woohyun Koh, Bo-Eun Yoon, Rolando Berlinguer-Palmini, Guido Mannaioni, Stephen F Traynelis, Yong Chul Bae, Se-Young Choi, C Justin Lee |
| Abstract |
BackgroundActivation of G protein coupled receptor (GPCR) in astrocytes leads to Ca2+-dependent glutamate release via Bestrophin 1 (Best1) channel. Whether receptor-mediated glutamate release from astrocytes can regulate synaptic plasticity remains to be fully understood.ResultsWe show here that Best1-mediated astrocytic glutamate activates the synaptic N-methyl-D-aspartate receptor (NMDAR) and modulates NMDAR-dependent synaptic plasticity. Our data show that activation of the protease-activated receptor 1 (PAR1) in hippocampal CA1 astrocytes elevates the glutamate concentration at Schaffer collateral-CA1 (SC-CA1) synapses, resulting in activation of GluN2A-containing NMDARs and NMDAR-dependent potentiation of synaptic responses. Furthermore, the threshold for inducing NMDAR-dependent long-term potentiation (LTP) is lowered when astrocytic glutamate release accompanied LTP induction, suggesting that astrocytic glutamate is significant in modulating synaptic plasticity.ConclusionsOur results provide direct evidence for the physiological importance of channel-mediated astrocytic glutamate in modulating neural circuit functions. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 88 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 2% |
| Egypt | 1 | 1% |
| Unknown | 85 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 16 | 18% |
| Researcher | 14 | 16% |
| Student > Master | 14 | 16% |
| Student > Bachelor | 13 | 15% |
| Professor > Associate Professor | 4 | 5% |
| Other | 10 | 11% |
| Unknown | 17 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 26 | 30% |
| Agricultural and Biological Sciences | 16 | 18% |
| Biochemistry, Genetics and Molecular Biology | 8 | 9% |
| Medicine and Dentistry | 8 | 9% |
| Computer Science | 2 | 2% |
| Other | 6 | 7% |
| Unknown | 22 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 March 2020.
All research outputs
#6,949,679
of 22,789,076 outputs
Outputs from Molecular Brain
#326
of 1,106 outputs
Outputs of similar age
#96,640
of 352,356 outputs
Outputs of similar age from Molecular Brain
#8
of 23 outputs
Altmetric has tracked 22,789,076 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 1,106 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one has gotten more attention than average, scoring higher than 69% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 352,356 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.