Title |
High-depth sequencing of over 750 genes supports linear progression of primary tumors and metastases in most patients with liver-limited metastatic colorectal cancer
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Published in |
Genome Biology, February 2015
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DOI | 10.1186/s13059-015-0589-1 |
Pubmed ID | |
Authors |
Iain Beehuat Tan, Simeen Malik, Kalpana Ramnarayanan, John R McPherson, Dan Liang Ho, Yuka Suzuki, Sarah Boonhsui Ng, Su Yan, Kiat Hon Lim, Dennis Koh, Chew Min Hoe, Chung Yip Chan, Rachel Ten, Brian KP Goh, Alexander YF Chung, Joanna Tan, Cheryl Xueli Chan, Su Ting Tay, Lezhava Alexander, Niranjan Nagarajan, Axel M Hillmer, Choon Leong Tang, Clarinda Chua, Bin Tean Teh, Steve Rozen, Patrick Tan |
Abstract |
Colorectal cancer with metastases limited to the liver (liver-limited mCRC) is a distinct clinical subset characterized by possible cure with surgery. We performed high-depth sequencing of over 750 cancer-associated genes and copy number profiling in matched primary, metastasis and normal tissues to characterize genomic progression in 18 patients with liver-limited mCRC. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 3 | 33% |
United States | 1 | 11% |
Singapore | 1 | 11% |
Unknown | 4 | 44% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 44% |
Scientists | 4 | 44% |
Science communicators (journalists, bloggers, editors) | 1 | 11% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 4% |
United Kingdom | 1 | 2% |
Germany | 1 | 2% |
Unknown | 52 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 19 | 34% |
Student > Ph. D. Student | 12 | 21% |
Student > Master | 6 | 11% |
Student > Bachelor | 4 | 7% |
Student > Doctoral Student | 3 | 5% |
Other | 5 | 9% |
Unknown | 7 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 17 | 30% |
Biochemistry, Genetics and Molecular Biology | 15 | 27% |
Medicine and Dentistry | 11 | 20% |
Computer Science | 2 | 4% |
Environmental Science | 1 | 2% |
Other | 2 | 4% |
Unknown | 8 | 14% |