Title |
The Mycobacterium tuberculosis Rv2540c DNA sequence encodes a bifunctional chorismate synthase
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Published in |
BMC Molecular and Cell Biology, April 2008
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DOI | 10.1186/1471-2091-9-13 |
Pubmed ID | |
Authors |
Fernanda Ely, José ES Nunes, Evelyn K Schroeder, Jeverson Frazzon, Mário S Palma, Diógenes S Santos, Luiz A Basso |
Abstract |
The emergence of multi- and extensively-drug resistant Mycobacterium tuberculosis strains has created an urgent need for new agents to treat tuberculosis (TB). The enzymes of shikimate pathway are attractive targets to the development of antitubercular agents because it is essential for M. tuberculosis and is absent from humans. Chorismate synthase (CS) is the seventh enzyme of this route and catalyzes the NADH- and FMN-dependent synthesis of chorismate, a precursor of aromatic amino acids, naphthoquinones, menaquinones, and mycobactins. Although the M. tuberculosis Rv2540c (aroF) sequence has been annotated to encode a chorismate synthase, there has been no report on its correct assignment and functional characterization of its protein product. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 1 | 3% |
Brazil | 1 | 3% |
Unknown | 28 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 6 | 20% |
Researcher | 4 | 13% |
Student > Bachelor | 4 | 13% |
Student > Master | 3 | 10% |
Librarian | 2 | 7% |
Other | 6 | 20% |
Unknown | 5 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 8 | 27% |
Biochemistry, Genetics and Molecular Biology | 7 | 23% |
Sports and Recreations | 2 | 7% |
Chemistry | 2 | 7% |
Immunology and Microbiology | 1 | 3% |
Other | 3 | 10% |
Unknown | 7 | 23% |