Early transplantation of human immature dental pulp stem cells from baby teeth to golden retriever muscular dystrophy (GRMD) dogs: Local or systemic?
Journal of Translational Medicine, July 2008
Irina Kerkis, Carlos E Ambrosio, Alexandre Kerkis, Daniele S Martins, Eder Zucconi, Simone AS Fonseca, Rosa M Cabral, Carlos MC Maranduba, Thais P Gaiad, Adriana C Morini, Natassia M Vieira, Marina P Brolio, Osvaldo A Sant'Anna, Maria A Miglino, Mayana Zatz
The golden retriever muscular dystrophy (GRMD) dogs represent the best available animal model for therapeutic trials aiming at the future treatment of human Duchenne muscular dystrophy (DMD). We have obtained a rare litter of six GRMD dogs (3 males and 3 females) born from an affected male and a carrier female which were submitted to a therapeutic trial with adult human stem cells to investigate their capacity to engraft into dogs muscles by local as compared to systemic injection without any immunosuppression.
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