Title |
Early transplantation of human immature dental pulp stem cells from baby teeth to golden retriever muscular dystrophy (GRMD) dogs: Local or systemic?
|
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Published in |
Journal of Translational Medicine, July 2008
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DOI | 10.1186/1479-5876-6-35 |
Pubmed ID | |
Authors |
Irina Kerkis, Carlos E Ambrosio, Alexandre Kerkis, Daniele S Martins, Eder Zucconi, Simone AS Fonseca, Rosa M Cabral, Carlos MC Maranduba, Thais P Gaiad, Adriana C Morini, Natassia M Vieira, Marina P Brolio, Osvaldo A Sant'Anna, Maria A Miglino, Mayana Zatz |
Abstract |
The golden retriever muscular dystrophy (GRMD) dogs represent the best available animal model for therapeutic trials aiming at the future treatment of human Duchenne muscular dystrophy (DMD). We have obtained a rare litter of six GRMD dogs (3 males and 3 females) born from an affected male and a carrier female which were submitted to a therapeutic trial with adult human stem cells to investigate their capacity to engraft into dogs muscles by local as compared to systemic injection without any immunosuppression. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 4 | 2% |
Iran, Islamic Republic of | 2 | 1% |
France | 1 | <1% |
United Kingdom | 1 | <1% |
Colombia | 1 | <1% |
Unknown | 189 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 35 | 18% |
Student > Ph. D. Student | 28 | 14% |
Student > Bachelor | 26 | 13% |
Researcher | 20 | 10% |
Student > Doctoral Student | 14 | 7% |
Other | 36 | 18% |
Unknown | 39 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 51 | 26% |
Agricultural and Biological Sciences | 47 | 24% |
Biochemistry, Genetics and Molecular Biology | 27 | 14% |
Immunology and Microbiology | 7 | 4% |
Engineering | 6 | 3% |
Other | 20 | 10% |
Unknown | 40 | 20% |