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Minocycline fails to modulate cerebrospinal fluid HIV infection or immune activation in chronic untreated HIV-1 infection: results of a pilot study

Overview of attention for article published in AIDS Research and Therapy, May 2011
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Title
Minocycline fails to modulate cerebrospinal fluid HIV infection or immune activation in chronic untreated HIV-1 infection: results of a pilot study
Published in
AIDS Research and Therapy, May 2011
DOI 10.1186/1742-6405-8-17
Pubmed ID
Authors

Emily L Ho, Serena S Spudich, Evelyn Lee, Dietmar Fuchs, Elizabeth Sinclair, Richard W Price

Abstract

Minocycline is a tetracycline antibiotic that has been shown to attenuate central nervous system (CNS) lentivirus infection, immune activation, and brain injury in model systems. To initiate assessment of minocycline as an adjuvant therapy in human CNS HIV infection, we conducted an open-labelled pilot study of its effects on cerebrospinal fluid (CSF) and blood biomarkers of infection and immune responses in 7 viremic subjects not taking antiretroviral therapy.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 15 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 33%
Student > Bachelor 3 20%
Student > Master 3 20%
Other 1 7%
Professor > Associate Professor 1 7%
Other 0 0%
Unknown 2 13%
Readers by discipline Count As %
Nursing and Health Professions 4 27%
Medicine and Dentistry 4 27%
Neuroscience 2 13%
Immunology and Microbiology 1 7%
Psychology 1 7%
Other 1 7%
Unknown 2 13%