Title |
Correlation between mutational status and survival and second cancer risk assessment in patients with gastrointestinal stromal tumors: a population-based study
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Published in |
World Journal of Surgical Oncology, January 2015
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DOI | 10.1186/s12957-015-0474-0 |
Pubmed ID | |
Authors |
Jordi Rubió-Casadevall, Joan Borràs, Maria Carmona-García, Alberto Ameijide, Allan Gonzalez-Vidal, Maria Ortiz, Ramon Bosch, Francesc Riu, David Parada, Esther Martí, Josefina Miró, Juan Sirvent, Jaume Galceran, Rafael Marcos-Gragera |
Abstract |
Gastrointestinal stromal tumors are sarcomas of the digestive tract characterized by mutations mainly located in the c-KIT or in the platelet-derived growth factor receptor (PDGFR)-alpha genes. Mutations in the BRAF gene have also been described. Our purpose is to define the distribution of c-KIT, PDGFR and BRAF mutations in a population-based cohort of gastrointestinal stromal tumors (GIST) patients and correlate them with anatomical site, risk classification and survival. In addition, as most of the GIST patients have a long survival, second cancers are frequently diagnosed in them. We performed a second primary cancer risk assessment. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 3% |
Unknown | 34 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 7 | 20% |
Librarian | 4 | 11% |
Other | 4 | 11% |
Student > Doctoral Student | 3 | 9% |
Student > Bachelor | 3 | 9% |
Other | 10 | 29% |
Unknown | 4 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 22 | 63% |
Veterinary Science and Veterinary Medicine | 2 | 6% |
Unspecified | 1 | 3% |
Nursing and Health Professions | 1 | 3% |
Computer Science | 1 | 3% |
Other | 3 | 9% |
Unknown | 5 | 14% |