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Mendeley readers
Title |
P-gp activity is a critical resistance factor against AVE9633 and DM4 cytotoxicity in leukaemia cell lines, but not a major mechanism of chemoresistance in cells from acute myeloid leukaemia patients
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Published in |
BMC Cancer, June 2009
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DOI | 10.1186/1471-2407-9-199 |
Pubmed ID | |
Authors |
Ruoping Tang, Simy Cohen, Jean-Yves Perrot, Anne-Marie Faussat, Claudia Zuany-Amorim, Zora Marjanovic, Hamid Morjani, Fanny Fava, Elise Corre, Ollivier Legrand, Jean-Pierre Marie |
Abstract |
AVE9633 is a new immunoconjugate comprising a humanized monoclonal antibody, anti-CD33 antigen, linked through a disulfide bond to the maytansine derivative DM4, a cytotoxic agent and potent tubulin inhibitor. It is undergoing a phase I clinical trial. Chemoresistance to anti-mitotic agents has been shown to be related, in part, to overexpression of ABC proteins. The aim of the present study was to investigate the potential roles of P-gp, MRP1 and BCRP in cytotoxicity in AVE9633-induced acute myeloid leukaemia (AML). |
Mendeley readers
The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 1 | 3% |
United States | 1 | 3% |
Unknown | 34 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 13 | 36% |
Student > Ph. D. Student | 6 | 17% |
Professor | 4 | 11% |
Student > Bachelor | 2 | 6% |
Student > Postgraduate | 2 | 6% |
Other | 6 | 17% |
Unknown | 3 | 8% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 12 | 33% |
Pharmacology, Toxicology and Pharmaceutical Science | 7 | 19% |
Chemistry | 4 | 11% |
Biochemistry, Genetics and Molecular Biology | 2 | 6% |
Medicine and Dentistry | 2 | 6% |
Other | 1 | 3% |
Unknown | 8 | 22% |