Title |
The chicken miR-150 targets the avian orthologue of the functional zebrafish MYB 3'UTR target site
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Published in |
BMC Molecular and Cell Biology, September 2010
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DOI | 10.1186/1471-2199-11-67 |
Pubmed ID | |
Authors |
Audrey Guillon-Munos, Ginette Dambrine, Nicolas Richerioux, Damien Coupeau, Benoît Muylkens, Denis Rasschaert |
Abstract |
The c-myb proto-oncogene is the founding member of a family of transcription factors involved principally in haematopoiesis, in diverse organisms, from zebrafish to mammals. Its deregulation has been implicated in human leukaemogenesis and other cancers. The expression of c-myb is tightly regulated by post-transcriptional mechanisms involving microRNAs. MicroRNAs are small, highly conserved non-coding RNAs that inhibit translation and decrease mRNA stability by binding to regulatory motifs mostly located in the 3'UTR of target mRNAs conserved throughout evolution. MYB is an evolutionarily conserved miR-150 target experimentally validated in mice, humans and zebrafish. However, the functional miR-150 sites of humans and mice are orthologous, whereas that of zebrafish is different. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 6% |
Unknown | 16 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 4 | 24% |
Researcher | 4 | 24% |
Student > Postgraduate | 2 | 12% |
Student > Ph. D. Student | 1 | 6% |
Student > Doctoral Student | 1 | 6% |
Other | 2 | 12% |
Unknown | 3 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 8 | 47% |
Biochemistry, Genetics and Molecular Biology | 3 | 18% |
Veterinary Science and Veterinary Medicine | 1 | 6% |
Medicine and Dentistry | 1 | 6% |
Chemistry | 1 | 6% |
Other | 0 | 0% |
Unknown | 3 | 18% |