Title |
Difference in gene duplicability may explain the difference in overall structure of protein-protein interaction networks among eukaryotes
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Published in |
BMC Evolutionary Biology, November 2010
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DOI | 10.1186/1471-2148-10-358 |
Pubmed ID | |
Authors |
Takeshi Hase, Yoshihito Niimura, Hiroshi Tanaka |
Abstract |
A protein-protein interaction network (PIN) was suggested to be a disassortative network, in which interactions between high- and low-degree nodes are favored while hub-hub interactions are suppressed. It was postulated that a disassortative structure minimizes unfavorable cross-talks between different hub-centric functional modules and was positively selected in evolution. However, by re-examining yeast PIN data, several researchers reported that the disassortative structure observed in a PIN might be an experimental artifact. Therefore, the existence of a disassortative structure and its possible evolutionary mechanism remains unclear. |
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Geographical breakdown
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United States | 4 | 10% |
United Kingdom | 2 | 5% |
Canada | 2 | 5% |
Netherlands | 1 | 2% |
Pakistan | 1 | 2% |
Japan | 1 | 2% |
Denmark | 1 | 2% |
Unknown | 29 | 71% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 14 | 34% |
Researcher | 11 | 27% |
Professor > Associate Professor | 6 | 15% |
Professor | 3 | 7% |
Student > Master | 2 | 5% |
Other | 2 | 5% |
Unknown | 3 | 7% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 20 | 49% |
Biochemistry, Genetics and Molecular Biology | 6 | 15% |
Computer Science | 3 | 7% |
Business, Management and Accounting | 2 | 5% |
Mathematics | 2 | 5% |
Other | 6 | 15% |
Unknown | 2 | 5% |