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Zinc-finger domains of the transcriptional repressor KLF15 bind multiple sites in rhodopsin and IRBP promoters including the CRS-1 and G-rich repressor elements

Overview of attention for article published in BMC Molecular and Cell Biology, June 2005
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Title
Zinc-finger domains of the transcriptional repressor KLF15 bind multiple sites in rhodopsin and IRBP promoters including the CRS-1 and G-rich repressor elements
Published in
BMC Molecular and Cell Biology, June 2005
DOI 10.1186/1471-2199-6-15
Pubmed ID
Authors

Deborah C Otteson, Hong Lai, Yuhui Liu, Donald J Zack

Abstract

In the retina, many of the genes that encode components of the visual transduction cascade and retinoid recycling are exclusively expressed in photoreceptor cells and show highly stereotyped temporal and spatial expression patterns. Multiple transcriptional activators of photoreceptor-specific genes have been identified, but little is known about negative regulation of gene expression in the retina. We recently identified KLF15, a member of the Sp/Krüppel-like Factor family of zinc-finger containing transcription factors, as an in vitro repressor of the promoters of the photoreceptor-specific genes rhodopsin and IRBP/Rbp3. To gain further insight into the mechanism of KLF15-mediated regulation of gene expression, we have characterized the binding characteristics and specificity of KLF15's DNA binding domains and defined the KLF15 binding sites in the rhodopsin and IRBP promoters.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 5%
Spain 1 3%
Malaysia 1 3%
Unknown 33 89%

Demographic breakdown

Readers by professional status Count As %
Researcher 11 30%
Student > Ph. D. Student 7 19%
Professor > Associate Professor 5 14%
Student > Master 4 11%
Student > Postgraduate 3 8%
Other 5 14%
Unknown 2 5%
Readers by discipline Count As %
Agricultural and Biological Sciences 20 54%
Biochemistry, Genetics and Molecular Biology 5 14%
Neuroscience 4 11%
Medicine and Dentistry 4 11%
Pharmacology, Toxicology and Pharmaceutical Science 1 3%
Other 0 0%
Unknown 3 8%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 May 2011.
All research outputs
#8,535,684
of 25,374,917 outputs
Outputs from BMC Molecular and Cell Biology
#334
of 1,233 outputs
Outputs of similar age
#23,855
of 66,739 outputs
Outputs of similar age from BMC Molecular and Cell Biology
#4
of 10 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,233 research outputs from this source. They receive a mean Attention Score of 4.0. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 66,739 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 6 of them.