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Lower vitamin D levels in Saudi pregnant women are associated with higher risk of developing GDM

Overview of attention for article published in BMC Pregnancy and Childbirth, April 2018
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Title
Lower vitamin D levels in Saudi pregnant women are associated with higher risk of developing GDM
Published in
BMC Pregnancy and Childbirth, April 2018
DOI 10.1186/s12884-018-1723-3
Pubmed ID
Authors

Abdulrahman Al-Ajlan, Sara Al-Musharaf, Mona A. Fouda, Soundararajan Krishnaswamy, Kaiser Wani, Naji J. Aljohani, Amal Al-Serehi, Eman Sheshah, Naemah M. Alshingetti, Iqbah Z. Turkistani, A. Afrah Alharbi, Buthaynah A. Alraqebah, Aisha Mansoor Ali, Gawaher Al-Saeed, Nasser M. Al-Daghri

Abstract

Gestational diabetes mellitus (GDM) has serious consequences such as increased risks of preeclampsia, macrosomia and cesarean delivery. Even though the mechanistic basis of GDM has not been completely understood, several risk factors have been identified and one of these is vitamin D. However, the link between vitamin D deficiency and development of GDM is yet to be proven with certainty. This study aimed to investigate the link between the incidence of GDM and serum vitamin D level in pregnant women of Saudi Arabia. 515 Saudi women (ages 18-46) in their 24-28th week of pregnancy, visiting various hospitals of Riyadh, participated in this study. Serum vitamin D and various biochemical and anthropometric parameters were determined in the first trimester and the recruits were screened for GDM by OGTT according to IADPSG criteria in their 2nd trimester. The association between vitamin D deficiency and development of GDM was calculated based on odds ratio of the incidence of GDM among vitamin D deficient and normal women. In this study cohort of 515 pregnant women, in the first trimester vitamin D deficiency (< 50 nmol/l) was detected in 425 (82.5%). On their 2nd visit (2nd trimester), 116 (27.7%) were diagnosed with GDM out of 419 with OGTT, according to IADPSG criteria. GDM risk was significantly higher among vitamin D deficient than non-deficient women (Odds Ratio: 2.87; Confidence Interval: 1.32-6.25; P = 0.008) even after adjusting for season, sun exposure and vitamin D intake (OR: 2.9; CI: 1.07-7.89). Of the various anthropometric and biochemical parameters, the GDM women differed significantly from non-GDM women with respect to serum levels of triglycerides (in mmol/l) (1.3 ± 0.6; 1.5 ± 0.6, p = 0.018) and fasting glucose (in mmol/l) [4.7 (4.3-5.2); 5.1 (4.6-5.6), p < 0.01]. Also, fasting glucose level in the 2nd trimester correlated inversely to serum vitamin D level determined during the 1st trimester (r = - 0.121; p = 0.014). Results of our study reveal a significantly higher risk of development of GDM among pregnant women having deficient vitamin D status.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 148 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 148 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 19 13%
Student > Bachelor 17 11%
Researcher 12 8%
Student > Postgraduate 9 6%
Other 7 5%
Other 21 14%
Unknown 63 43%
Readers by discipline Count As %
Medicine and Dentistry 37 25%
Nursing and Health Professions 12 8%
Biochemistry, Genetics and Molecular Biology 6 4%
Pharmacology, Toxicology and Pharmaceutical Science 5 3%
Immunology and Microbiology 3 2%
Other 11 7%
Unknown 74 50%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 April 2018.
All research outputs
#19,292,491
of 23,881,329 outputs
Outputs from BMC Pregnancy and Childbirth
#3,617
of 4,379 outputs
Outputs of similar age
#259,487
of 331,343 outputs
Outputs of similar age from BMC Pregnancy and Childbirth
#97
of 106 outputs
Altmetric has tracked 23,881,329 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,379 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.0. This one is in the 9th percentile – i.e., 9% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 331,343 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 106 others from the same source and published within six weeks on either side of this one. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.