Title |
The endocannabinoid anandamide is a precursor for the signaling lipid N-arachidonoyl glycine by two distinct pathways
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Published in |
BMC Molecular and Cell Biology, May 2009
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DOI | 10.1186/1471-2091-10-14 |
Pubmed ID | |
Authors |
Heather B Bradshaw, Neta Rimmerman, Sherry Shu-Jung Hu, Valery M Benton, Jordyn M Stuart, Kim Masuda, Benjamin F Cravatt, David K O'Dell, J Michael Walker |
Abstract |
N-arachidonoyl glycine (NAGly) is an endogenous signaling lipid with a wide variety of biological activity whose biosynthesis is poorly understood. Two primary biosynthetic pathways have been proposed. One suggests that NAGly is formed via an enzymatically regulated conjugation of arachidonic acid (AA) and glycine. The other suggests that NAGly is an oxidative metabolite of the endogenous cannabinoid, anandamide (AEA), through an alcohol dehydrogenase. Here using both in vitro and in vivo assays measuring metabolites with LC/MS/MS we test the hypothesis that both pathways are present in mammalian cells. |
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Geographical breakdown
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United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 2 | 3% |
United States | 1 | 1% |
Unknown | 77 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 19 | 24% |
Researcher | 18 | 23% |
Student > Master | 7 | 9% |
Student > Bachelor | 6 | 8% |
Student > Doctoral Student | 6 | 8% |
Other | 17 | 21% |
Unknown | 7 | 9% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 22 | 28% |
Biochemistry, Genetics and Molecular Biology | 10 | 13% |
Medicine and Dentistry | 7 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 8% |
Neuroscience | 5 | 6% |
Other | 15 | 19% |
Unknown | 15 | 19% |