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The synovial proteome: analysis of fibroblast-like synoviocytes

Overview of attention for article published in Arthritis Research & Therapy, February 2004
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Mentioned by

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2 Wikipedia pages

Citations

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80 Dimensions

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56 Mendeley
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Title
The synovial proteome: analysis of fibroblast-like synoviocytes
Published in
Arthritis Research & Therapy, February 2004
DOI 10.1186/ar1153
Pubmed ID
Authors

Kumar Dasuri, Mihaela Antonovici, Keding Chen, Ken Wong, Kenneth Standing, Werner Ens, Hani El-Gabalawy, John A Wilkins

Abstract

The present studies were initiated to determine the protein expression patterns of fibroblast-like synovial (FLS) cells derived from the synovia of rheumatoid arthritis patients. The cellular proteins were separated by two-dimensional polyacrylamide gel electrophoresis and the in-gel digested proteins were analyzed by matrix-assisted laser desorption ionization mass spectrometry. A total of 368 spots were examined and 254 identifications were made. The studies identified a number of proteins that have been implicated in the normal or pathological FLS function (e.g. uridine diphosphoglucose dehydrogenase, galectin 1 and galectin 3) or that have been characterized as potential autoantigens in rheumatoid arthritis (e.g. BiP, colligin, HC gp-39). A novel uncharacterized protein product of chromosome 19 open reading frame 10 was also detected as an apparently major component of FLS cells. These results demonstrate the utility of high-content proteomic approaches in the analysis of FLS composition.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Sweden 1 2%
Unknown 55 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 23%
Student > Master 9 16%
Researcher 7 13%
Professor 6 11%
Student > Doctoral Student 5 9%
Other 10 18%
Unknown 6 11%
Readers by discipline Count As %
Medicine and Dentistry 15 27%
Agricultural and Biological Sciences 11 20%
Biochemistry, Genetics and Molecular Biology 9 16%
Engineering 4 7%
Pharmacology, Toxicology and Pharmaceutical Science 2 4%
Other 8 14%
Unknown 7 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 October 2012.
All research outputs
#8,535,472
of 25,374,647 outputs
Outputs from Arthritis Research & Therapy
#1,710
of 3,381 outputs
Outputs of similar age
#22,265
of 62,364 outputs
Outputs of similar age from Arthritis Research & Therapy
#4
of 9 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,381 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one is in the 38th percentile – i.e., 38% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 62,364 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 5 of them.