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Mechanism of action of lenalidomide in hematological malignancies

Overview of attention for article published in Journal of Hematology & Oncology, August 2009
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)

Mentioned by

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1 blog
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2 X users
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5 patents
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9 Wikipedia pages

Citations

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382 Dimensions

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385 Mendeley
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Title
Mechanism of action of lenalidomide in hematological malignancies
Published in
Journal of Hematology & Oncology, August 2009
DOI 10.1186/1756-8722-2-36
Pubmed ID
Authors

Venumadhav Kotla, Swati Goel, Sangeeta Nischal, Christoph Heuck, Kumar Vivek, Bhaskar Das, Amit Verma

Abstract

Immunomodulatory drugs lenalidomide and pomalidomide are synthetic compounds derived by modifying the chemical structure of thalidomide to improve its potency and reduce its side effects. Lenalidomide is a 4-amino-glutamyl analogue of thalidomide that lacks the neurologic side effects of sedation and neuropathy and has emerged as a drug with activity against various hematological and solid malignancies. It is approved by FDA for clinical use in myelodysplastic syndromes with deletion of chromosome 5q and multiple myeloma. Lenalidomide has been shown to be an immunomodulator, affecting both cellular and humoral limbs of the immune system. It has also been shown to have anti-angiogenic properties. Newer studies demonstrate its effects on signal transduction that can partly explain its selective efficacy in subsets of MDS. Even though the exact molecular targets of lenalidomide are not well known, its activity across a spectrum of neoplastic conditions highlights the possibility of multiple target sites of action.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 385 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 <1%
United States 2 <1%
Belgium 1 <1%
Netherlands 1 <1%
Japan 1 <1%
Spain 1 <1%
Unknown 377 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 68 18%
Student > Bachelor 45 12%
Student > Ph. D. Student 44 11%
Student > Master 43 11%
Other 28 7%
Other 56 15%
Unknown 101 26%
Readers by discipline Count As %
Medicine and Dentistry 111 29%
Biochemistry, Genetics and Molecular Biology 51 13%
Agricultural and Biological Sciences 40 10%
Pharmacology, Toxicology and Pharmaceutical Science 20 5%
Chemistry 14 4%
Other 41 11%
Unknown 108 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 21. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 April 2024.
All research outputs
#1,707,480
of 24,393,999 outputs
Outputs from Journal of Hematology & Oncology
#112
of 1,261 outputs
Outputs of similar age
#5,460
of 116,770 outputs
Outputs of similar age from Journal of Hematology & Oncology
#1
of 3 outputs
Altmetric has tracked 24,393,999 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,261 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.8. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 116,770 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them