Title |
The primordial metabolism: an ancestral interconnection between leucine, arginine, and lysine biosynthesis
|
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Published in |
BMC Ecology and Evolution, August 2007
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DOI | 10.1186/1471-2148-7-s2-s3 |
Pubmed ID | |
Authors |
Marco Fondi, Matteo Brilli, Giovanni Emiliani, Donatella Paffetti, Renato Fani |
Abstract |
It is generally assumed that primordial cells had small genomes with simple genes coding for enzymes able to react with a wide range of chemically related substrates, interconnecting different metabolic routes. New genes coding for enzymes with a narrowed substrate specificity arose by paralogous duplication(s) of ancestral ones and evolutionary divergence. In this way new metabolic pathways were built up by primordial cells. Useful hints to disclose the origin and evolution of ancestral metabolic routes and their interconnections can be obtained by comparing sequences of enzymes involved in the same or different metabolic routes. From this viewpoint, the lysine, arginine, and leucine biosynthetic routes represent very interesting study-models. Some of the lys, arg and leu genes are paralogs; this led to the suggestion that their ancestor genes might interconnect the three pathways. The aim of this work was to trace the evolutionary pathway leading to the appearance of the extant biosynthetic routes and to try to disclose the interrelationships existing between them and other pathways in the early stages of cellular evolution. |
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