Title |
Information-theoretic gene-gene and gene-environment interaction analysis of quantitative traits
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Published in |
BMC Genomics, November 2009
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DOI | 10.1186/1471-2164-10-509 |
Pubmed ID | |
Authors |
Pritam Chanda, Lara Sucheston, Song Liu, Aidong Zhang, Murali Ramanathan |
Abstract |
The purpose of this research was to develop a novel information theoretic method and an efficient algorithm for analyzing the gene-gene (GGI) and gene-environmental interactions (GEI) associated with quantitative traits (QT). The method is built on two information-theoretic metrics, the k-way interaction information (KWII) and phenotype-associated information (PAI). The PAI is a novel information theoretic metric that is obtained from the total information correlation (TCI) information theoretic metric by removing the contributions for inter-variable dependencies (resulting from factors such as linkage disequilibrium and common sources of environmental pollutants). |
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