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Mendeley readers
| Title |
The activation mechanism of Irga6, an interferon-inducible GTPase contributing to mouse resistance against Toxoplasma gondii
|
|---|---|
| Published in |
BMC Biology, January 2011
|
| DOI | 10.1186/1741-7007-9-7 |
| Pubmed ID | |
| Authors |
Nikolaus Pawlowski, Aliaksandr Khaminets, Julia P Hunn, Natasa Papic, Andreas Schmidt, Revathy C Uthaiah, Rita Lange, Gabriela Vopper, Sascha Martens, Eva Wolf, Jonathan C Howard |
| Abstract |
The interferon-inducible immunity-related GTPases (IRG proteins/p47 GTPases) are a distinctive family of GTPases that function as powerful cell-autonomous resistance factors. The IRG protein, Irga6 (IIGP1), participates in the disruption of the vacuolar membrane surrounding the intracellular parasite, Toxoplasma gondii, through which it communicates with its cellular hosts. Some aspects of the protein's behaviour have suggested a dynamin-like molecular mode of action, in that the energy released by GTP hydrolysis is transduced into mechanical work that results in deformation and ultimately rupture of the vacuolar membrane. |
Mendeley readers
The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 2 | 5% |
| United States | 1 | 2% |
| Unknown | 41 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 25% |
| Researcher | 7 | 16% |
| Student > Bachelor | 4 | 9% |
| Student > Master | 4 | 9% |
| Professor | 4 | 9% |
| Other | 5 | 11% |
| Unknown | 9 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 22 | 50% |
| Biochemistry, Genetics and Molecular Biology | 6 | 14% |
| Immunology and Microbiology | 4 | 9% |
| Nursing and Health Professions | 1 | 2% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
| Other | 0 | 0% |
| Unknown | 10 | 23% |