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Mendeley readers
Attention Score in Context
| Title |
Targeting aspartate aminotransferase in breast cancer
|
|---|---|
| Published in |
Breast Cancer Research, October 2008
|
| DOI | 10.1186/bcr2154 |
| Pubmed ID | |
| Authors |
Joshua Marshall Thornburg, Kristin K Nelson, Brian F Clem, Andrew N Lane, Sengodagounder Arumugam, Allan Simmons, John W Eaton, Sucheta Telang, Jason Chesney |
| Abstract |
Glycolysis is increased in breast adenocarcinoma cells relative to adjacent normal cells in order to produce the ATP and anabolic precursors required for survival, growth and invasion. Glycolysis also serves as a key source of the reduced form of cytoplasmic nicotinamide adenine dinucleotide (NADH) necessary for the shuttling of electrons into mitochondria for electron transport. Lactate dehydrogenase (LDH) regulates glycolytic flux by converting pyruvate to lactate and has been found to be highly expressed in breast tumours. Aspartate aminotransferase (AAT) functions in tandem with malate dehydrogenase to transfer electrons from NADH across the inner mitochondrial membrane. Oxamate is an inhibitor of both LDH and AAT, and we hypothesised that oxamate may disrupt the metabolism and growth of breast adenocarcinoma cells. |
Mendeley readers
The data shown below were compiled from readership statistics for 198 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 1% |
| United States | 2 | 1% |
| Czechia | 1 | <1% |
| Mexico | 1 | <1% |
| Germany | 1 | <1% |
| Unknown | 191 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 55 | 28% |
| Researcher | 34 | 17% |
| Student > Bachelor | 15 | 8% |
| Student > Master | 13 | 7% |
| Professor | 8 | 4% |
| Other | 25 | 13% |
| Unknown | 48 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 47 | 24% |
| Biochemistry, Genetics and Molecular Biology | 41 | 21% |
| Chemistry | 17 | 9% |
| Medicine and Dentistry | 16 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 4% |
| Other | 16 | 8% |
| Unknown | 54 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 May 2023.
All research outputs
#3,798,287
of 25,371,288 outputs
Outputs from Breast Cancer Research
#451
of 2,052 outputs
Outputs of similar age
#12,332
of 102,804 outputs
Outputs of similar age from Breast Cancer Research
#3
of 15 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,052 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.2. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 102,804 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.