Title |
An approach to evaluate the topological significance of motifs and other patterns in regulatory networks
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Published in |
BMC Systems Biology, May 2009
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DOI | 10.1186/1752-0509-3-53 |
Pubmed ID | |
Authors |
Björn Goemann, Edgar Wingender, Anatolij P Potapov |
Abstract |
The identification of network motifs as statistically over-represented topological patterns has become one of the most promising topics in the analysis of complex networks. The main focus is commonly made on how they operate by means of their internal organization. Yet, their contribution to a network's global architecture is poorly understood. However, this requires switching from the abstract view of a topological pattern to the level of its instances. Here, we show how a recently proposed metric, the pairwise disconnectivity index, can be adapted to survey if and which kind of topological patterns and their instances are most important for sustaining the connectivity within a network. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 4% |
Portugal | 1 | 4% |
Germany | 1 | 4% |
Unknown | 22 | 88% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 9 | 36% |
Researcher | 8 | 32% |
Professor | 3 | 12% |
Professor > Associate Professor | 3 | 12% |
Student > Master | 1 | 4% |
Other | 1 | 4% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 12 | 48% |
Engineering | 5 | 20% |
Computer Science | 3 | 12% |
Mathematics | 1 | 4% |
Psychology | 1 | 4% |
Other | 1 | 4% |
Unknown | 2 | 8% |