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INTS6/DICE1 inhibits growth of human androgen-independent prostate cancer cells by altering the cell cycle profile and Wnt signaling

Overview of attention for article published in Cancer Cell International, November 2009
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Title
INTS6/DICE1 inhibits growth of human androgen-independent prostate cancer cells by altering the cell cycle profile and Wnt signaling
Published in
Cancer Cell International, November 2009
DOI 10.1186/1475-2867-9-28
Pubmed ID
Authors

Stephanie Filleur, Jennifer Hirsch, Aline Wille, Margarete Schön, Christian Sell, Michael H Shearer, Thomas Nelius, Ilse Wieland

Abstract

The gene encoding integrator complex subunit 6 (INTS6), previously known as deleted in cancer cells 1 (DICE1, OMIM 604331) was found to be frequently affected by allelic deletion and promoter hypermethylation in prostate cancer specimens and cell lines. A missense mutation has been detected in prostate cancer cell line LNCaP. Together, these results suggest INTS6/DICE1 as a putative tumor suppressor gene in prostate cancer. In this study, we examined the growth inhibitory effects of INTS6/DICE1 on prostate cancer cells.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 30 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 6 20%
Student > Ph. D. Student 4 13%
Researcher 4 13%
Student > Master 2 7%
Student > Doctoral Student 1 3%
Other 3 10%
Unknown 10 33%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 8 27%
Agricultural and Biological Sciences 8 27%
Medicine and Dentistry 2 7%
Unknown 12 40%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 August 2011.
All research outputs
#8,535,472
of 25,374,917 outputs
Outputs from Cancer Cell International
#1,002
of 2,231 outputs
Outputs of similar age
#37,915
of 106,658 outputs
Outputs of similar age from Cancer Cell International
#1
of 2 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,231 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.2. This one has gotten more attention than average, scoring higher than 51% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 106,658 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 19th percentile – i.e., 19% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them