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Mendeley readers
Attention Score in Context
| Title |
Loss of Angiopoietin-like 7 diminishes the regeneration capacity of hematopoietic stem and progenitor cells
|
|---|---|
| Published in |
Journal of Hematology & Oncology, February 2015
|
| DOI | 10.1186/s13045-014-0102-4 |
| Pubmed ID | |
| Authors |
Yiren Xiao, Xinru Wei, Zhiwu Jiang, Xiangmeng Wang, Wei Ye, Xin Liu, Minjie Zhang, Yan Xu, Donghai Wu, Liangxue Lai, Huihui Yao, Zixia Liu, Su Cao, Pentao Liu, Bing Xu, Yangqiu Li, Yao Yao, Duanqing Pei, Peng Li |
| Abstract |
Successful expansion of hematopoietic stem cells (HSCs) would benefit the use of HSC transplants in the clinic. Angiopoietin-like 7 promotes the expansion of hematopoietic stem and progenitor cells (HSPC) in vitro and ex vivo. However, the impact of loss of Angptl7 on HSPCs in vivo has not been characterized. Here, we generated Angptl7-deficient mice by TALEN-mediated gene targeting and found that HSC compartments in Angptl7-null mice were compromised. In addition, wild type (WT) HSPCs failed to repopulate in the BM of Angptl7-null mice after serial transplantations while the engraftment of Angptl7-deficient HSPCs in WT mice was not impaired. These results suggest that Angptl7 is required for HSPCs repopulation in a non-cell autonomous manner. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 21 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 5 | 24% |
| Other | 2 | 10% |
| Student > Doctoral Student | 2 | 10% |
| Professor | 1 | 5% |
| Librarian | 1 | 5% |
| Other | 4 | 19% |
| Unknown | 6 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 3 | 14% |
| Agricultural and Biological Sciences | 3 | 14% |
| Medicine and Dentistry | 3 | 14% |
| Engineering | 2 | 10% |
| Computer Science | 1 | 5% |
| Other | 2 | 10% |
| Unknown | 7 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 January 2024.
All research outputs
#4,617,308
of 23,206,358 outputs
Outputs from Journal of Hematology & Oncology
#357
of 1,204 outputs
Outputs of similar age
#66,638
of 354,056 outputs
Outputs of similar age from Journal of Hematology & Oncology
#2
of 19 outputs
Altmetric has tracked 23,206,358 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,204 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.4. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 354,056 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.